<\/p>\n\n\n\n
Autor \u010dl\u00e1nku, spolupracovn\u00edk Medu\u0148ky prof. Ing. Pavel VAL\u00cd\u010cEK DrSc. <\/strong>vysv\u011btluje p\u0159\u00ednos l\u00e1tky resveratrol<\/strong>, obsa\u017een\u00e9 ve v\u00edn\u011b, pro na\u0161e zdrav\u00ed. Ve druh\u00e9 \u010d\u00e1sti \u010dl\u00e1nku (viz n\u00ed\u017ee) se zam\u011b\u0159uje na vliv resveratrolu p\u0159i onemocn\u011bn\u00ed cukrovkou a p\u0159i onkologick\u00fdch chorob\u00e1ch… Ov\u0161em spole\u010dn\u011b s panem profesorem Val\u00ed\u010dkem p\u0159ipom\u00edn\u00e1me, \u017ee v\u00edno sice l\u00e9\u010d\u00ed – ale V\u0160EHO S M\u00cdROU!<\/strong><\/p>\n\n\n\n <\/p>\n\n\n\n Pom\u00e1h\u00e1 p\u0159i cukrovce a rakovin\u011b<\/strong> <\/p>\n\n\n\n Prevence a l\u00e9\u010dba diabetu<\/strong> Autor \u010dl\u00e1nku, spolupracovn\u00edk Medu\u0148ky prof. Ing. Pavel VAL\u00cd\u010cEK DrSc. vysv\u011btluje p\u0159\u00ednos l\u00e1tky resveratrol, obsa\u017een\u00e9 ve v\u00edn\u011b, pro na\u0161e zdrav\u00ed. Ve druh\u00e9 \u010d\u00e1sti \u010dl\u00e1nku (viz n\u00ed\u017ee) se zam\u011b\u0159uje na vliv resveratrolu p\u0159i onemocn\u011bn\u00ed cukrovkou a p\u0159i onkologick\u00fdch chorob\u00e1ch… Ov\u0161em spole\u010dn\u011b s panem profesorem Val\u00ed\u010dkem p\u0159ipom\u00edn\u00e1me, \u017ee v\u00edno sice l\u00e9\u010d\u00ed – ale V\u0160EHO S M\u00cdROU! Pom\u00e1h\u00e1 p\u0159i cukrovce a rakovin\u011bV souvislosti s polyfenoly je t\u0159eba se tak\u00e9 zm\u00ednit o sirtuinech. Pokusy prokazuj\u00ed, \u017ee drastick\u00e9 omezen\u00ed kalorick\u00e9ho p\u0159\u00edjmu v potrav\u011b prodlou\u017e\u00ed \u017eivot pokusn\u00fdm zv\u00ed\u0159at\u016fm a\u017e o 40 % a z\u00e1rove\u0148 zvy\u0161uje jejich odolnost k nemocem projevuj\u00edc\u00edm se v pokro\u010dil\u00e9m st\u00e1\u0159\u00ed. V praxi to znamen\u00e1, \u017ee pln\u011b plat\u00ed star\u00e9 \u010desk\u00e9 p\u0159\u00edslov\u00ed \u201ejez do polosyta, pij do propita, vyjdou ti naplno l\u00e9ta\u201c.P\u0159i n\u00edzk\u00e9m p\u0159\u00edjmu energie, ale dostatku ostatn\u00edch d\u016fle\u017eit\u00fdch \u017eivin, nap\u0159. vitamin\u016f, miner\u00e1ln\u00edch l\u00e1tek aj. se u v\u011bt\u0161iny \u017eiv\u00fdch organism\u016f aktivuj\u00ed geny zodpov\u011bdn\u00e9 za v\u00fdrobu b\u00edlkovin ze skupiny sirtuin\u016f. Sirtuiny potom aktivuj\u00ed enzymy, kter\u00e9 n\u00e1sledn\u011b chr\u00e1n\u00ed d\u011bdi\u010dnou informaci p\u0159ed po\u0161kozen\u00edm. \u017divotn\u011b d\u016fle\u017eit\u00e9 geny d\u00edky tomu vydr\u017e\u00ed d\u00e9le pracovat tak, jak je t\u0159eba a neohro\u017euj\u00ed na\u0161e t\u011blo t\u0159eba rakovinn\u00fdm bujen\u00edm nebo jin\u00fdmi z\u00e1va\u017en\u00fdmi chorobami.Touto problematikou se zab\u00fdval David Sinclair z Harvard Medical School a gen, kter\u00fd je za toto zodpov\u011bdn\u00fd u \u010dlov\u011bka je zn\u00e1m jako SIRT1. Ovl\u00e1dat se d\u00e1 n\u011bkter\u00fdmi l\u00e1tkami ze skupiny polyfenol\u016f, p\u0159edev\u0161\u00edm resveratrolem. Ten zvy\u0161uje aktivitu tohoto \u017eivotod\u00e1rn\u00e9ho genu v lidsk\u00fdch bu\u0148k\u00e1ch a\u017e 13kr\u00e1t. Bylo prok\u00e1z\u00e1no, \u017ee sirtuin prost\u0159ednictv\u00edm dal\u0161\u00edch mechanism\u016f v t\u011ble nejen \u201eopravuje\u201c po\u0161kozenou DNA, ale i pozitivn\u011b ovliv\u0148uje protein Bax, kter\u00fd je jednou z kl\u00ed\u010dov\u00fdch molekul spou\u0161t\u011bj\u00edc\u00ed tzv. apopt\u00f3zu, co\u017e je \u201esebevra\u017eda\u201c bu\u0148ky. Nav\u00edc tak\u00e9 likviduje ulo\u017een\u00fd t\u011bln\u00ed tuk. Prevence a l\u00e9\u010dba diabetuNov\u011bj\u0161\u00ed v\u00fdzkumy potom potvrzuj\u00ed, \u017ee resveratrol nab\u00edz\u00ed \u0159adu mo\u017enost\u00ed v prevenci i l\u00e9\u010db\u011b diabetu. D\u00edky tomu, \u017ee zv\u00fd\u0161en\u00e1 aktivita SIRT1 zp\u016fsobuje lep\u0161\u00ed citlivost inzul\u00ednu a t\u00edm sni\u017euje hladinu gluk\u00f3zy v krvi. Resveratrol a nebo p\u0159\u00edbuzn\u00e9 slou\u010deniny by mohly b\u00fdt pou\u017eity k zablokov\u00e1n\u00ed \u0161kodliv\u00fdch \u00fa\u010dink\u016f gluk\u00f3zy. Diabetici II. typu maj\u00ed b\u00edlkovinu amyllin, kter\u00e1 se uvol\u0148uje do bu\u0148ky pankreatu spolu s inzul\u00ednem. Tvo\u0159\u00ed tam uvnit\u0159 bun\u011bk pevn\u00e1 vl\u00e1kna a ta j\u00ed po\u0161kozuj\u00ed. Je to pr\u00e1v\u011b resveratrol, kter\u00fd tvo\u0159en\u00ed t\u011bchto vl\u00e1ken zamezuje.Velmi zaj\u00edmav\u00e9 jsou i v\u00fdsledky u nemocn\u00fdch rakovinou pankreatu, kter\u00fd je velmi odoln\u00fd v\u016f\u010di chemoterapii. Je to d\u00e1no t\u00edm, \u017ee neust\u00e1l\u00e1 tvorba tr\u00e1vic\u00edch enzym\u016f chemoterapeutika \u201esplachuje\u201c, a sni\u017euje t\u00edm jejich \u00fa\u010dinnost. Ukazuje se, \u017ee resveratrol oslabuje rakovinn\u00e9 bu\u0148ky pankreatu a nav\u00edc zv\u011bt\u0161uje jejich citlivost v\u016f\u010di chemoterapii.Resveratrol p\u016fsob\u00ed pozitivn\u011b i p\u0159i hromad\u011bn\u00ed tuku v j\u00e1trech, zp\u016fsoben\u00e9m po\u017e\u00edv\u00e1n\u00edm alkoholu. Ten br\u00e1n\u00ed \u010dinnosti dvou protein\u016f, a to AMPK a SIRT1, kter\u00e9 hraj\u00ed v\u00fdznamnou roli v ukl\u00e1d\u00e1n\u00ed tuk\u016f a jejich odstran\u011bn\u00ed z jater. Porucha m\u00e1 za n\u00e1sledek tvorbu jatern\u00edch chorob, jako je fibr\u00f3za nebo cirh\u00f3za. P\u0159i pokusech proveden\u00fdch na my\u0161\u00edch se uk\u00e1zalo, \u017ee u jedinc\u016f s p\u0159\u00edsunem resveratrolu se vytv\u00e1\u0159\u00ed daleko m\u00e9n\u011b tuku.<\/p>\n","protected":false},"author":3,"featured_media":3708,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,12],"tags":[],"class_list":["post-3705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medunka","category-vyziva-a-zdrava-strava"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/posts\/3705","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/comments?post=3705"}],"version-history":[{"count":3,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/posts\/3705\/revisions"}],"predecessor-version":[{"id":3709,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/posts\/3705\/revisions\/3709"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/media\/3708"}],"wp:attachment":[{"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/media?parent=3705"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/categories?post=3705"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mojemedunka.cz\/index.php\/wp-json\/wp\/v2\/tags?post=3705"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
V souvislosti s polyfenoly je t\u0159eba se tak\u00e9 zm\u00ednit o sirtuinech. Pokusy prokazuj\u00ed, \u017ee drastick\u00e9 omezen\u00ed kalorick\u00e9ho p\u0159\u00edjmu v potrav\u011b prodlou\u017e\u00ed \u017eivot pokusn\u00fdm zv\u00ed\u0159at\u016fm a\u017e o 40 % a z\u00e1rove\u0148 zvy\u0161uje jejich odolnost k nemocem projevuj\u00edc\u00edm se v pokro\u010dil\u00e9m st\u00e1\u0159\u00ed. V praxi to znamen\u00e1, \u017ee pln\u011b plat\u00ed star\u00e9 \u010desk\u00e9 p\u0159\u00edslov\u00ed \u201ejez do polosyta, pij do propita, vyjdou ti naplno l\u00e9ta\u201c.
P\u0159i n\u00edzk\u00e9m p\u0159\u00edjmu energie, ale dostatku ostatn\u00edch d\u016fle\u017eit\u00fdch \u017eivin, nap\u0159. vitamin\u016f, miner\u00e1ln\u00edch l\u00e1tek aj. se u v\u011bt\u0161iny \u017eiv\u00fdch organism\u016f aktivuj\u00ed geny zodpov\u011bdn\u00e9 za v\u00fdrobu b\u00edlkovin ze skupiny sirtuin\u016f. Sirtuiny potom aktivuj\u00ed enzymy, kter\u00e9 n\u00e1sledn\u011b chr\u00e1n\u00ed d\u011bdi\u010dnou informaci p\u0159ed po\u0161kozen\u00edm. \u017divotn\u011b d\u016fle\u017eit\u00e9 geny d\u00edky tomu vydr\u017e\u00ed d\u00e9le pracovat tak, jak je t\u0159eba a neohro\u017euj\u00ed na\u0161e t\u011blo t\u0159eba rakovinn\u00fdm bujen\u00edm nebo jin\u00fdmi z\u00e1va\u017en\u00fdmi chorobami.
Touto problematikou se zab\u00fdval David Sinclair z Harvard Medical School a gen, kter\u00fd je za toto zodpov\u011bdn\u00fd u \u010dlov\u011bka je zn\u00e1m jako SIRT1. Ovl\u00e1dat se d\u00e1 n\u011bkter\u00fdmi l\u00e1tkami ze skupiny polyfenol\u016f, p\u0159edev\u0161\u00edm resveratrolem. Ten zvy\u0161uje aktivitu tohoto \u017eivotod\u00e1rn\u00e9ho genu v lidsk\u00fdch bu\u0148k\u00e1ch a\u017e 13kr\u00e1t. Bylo prok\u00e1z\u00e1no, \u017ee sirtuin prost\u0159ednictv\u00edm dal\u0161\u00edch mechanism\u016f v t\u011ble nejen \u201eopravuje\u201c po\u0161kozenou DNA, ale i pozitivn\u011b ovliv\u0148uje protein Bax, kter\u00fd je jednou z kl\u00ed\u010dov\u00fdch molekul spou\u0161t\u011bj\u00edc\u00ed tzv. apopt\u00f3zu, co\u017e je \u201esebevra\u017eda\u201c bu\u0148ky. Nav\u00edc tak\u00e9 likviduje ulo\u017een\u00fd t\u011bln\u00ed tuk.<\/p>\n\n\n\n
Nov\u011bj\u0161\u00ed v\u00fdzkumy potom potvrzuj\u00ed, \u017ee resveratrol nab\u00edz\u00ed \u0159adu mo\u017enost\u00ed v prevenci i l\u00e9\u010db\u011b diabetu. D\u00edky tomu, \u017ee zv\u00fd\u0161en\u00e1 aktivita SIRT1 zp\u016fsobuje lep\u0161\u00ed citlivost inzul\u00ednu a t\u00edm sni\u017euje hladinu gluk\u00f3zy v krvi. Resveratrol a nebo p\u0159\u00edbuzn\u00e9 slou\u010deniny by mohly b\u00fdt pou\u017eity k zablokov\u00e1n\u00ed \u0161kodliv\u00fdch \u00fa\u010dink\u016f gluk\u00f3zy. Diabetici II. typu maj\u00ed b\u00edlkovinu amyllin, kter\u00e1 se uvol\u0148uje do bu\u0148ky pankreatu spolu s inzul\u00ednem. Tvo\u0159\u00ed tam uvnit\u0159 bun\u011bk pevn\u00e1 vl\u00e1kna a ta j\u00ed po\u0161kozuj\u00ed. Je to pr\u00e1v\u011b resveratrol, kter\u00fd tvo\u0159en\u00ed t\u011bchto vl\u00e1ken zamezuje.
Velmi zaj\u00edmav\u00e9 jsou i v\u00fdsledky u nemocn\u00fdch rakovinou pankreatu, kter\u00fd je velmi odoln\u00fd v\u016f\u010di chemoterapii. Je to d\u00e1no t\u00edm, \u017ee neust\u00e1l\u00e1 tvorba tr\u00e1vic\u00edch enzym\u016f chemoterapeutika \u201esplachuje\u201c, a sni\u017euje t\u00edm jejich \u00fa\u010dinnost. Ukazuje se, \u017ee resveratrol oslabuje rakovinn\u00e9 bu\u0148ky pankreatu a nav\u00edc zv\u011bt\u0161uje jejich citlivost v\u016f\u010di chemoterapii.
Resveratrol p\u016fsob\u00ed pozitivn\u011b i p\u0159i hromad\u011bn\u00ed tuku v j\u00e1trech, zp\u016fsoben\u00e9m po\u017e\u00edv\u00e1n\u00edm alkoholu.<\/strong> Ten br\u00e1n\u00ed \u010dinnosti dvou protein\u016f, a to AMPK a SIRT1, kter\u00e9 hraj\u00ed v\u00fdznamnou roli v ukl\u00e1d\u00e1n\u00ed tuk\u016f a jejich odstran\u011bn\u00ed z jater. Porucha m\u00e1 za n\u00e1sledek tvorbu jatern\u00edch chorob, jako je fibr\u00f3za nebo cirh\u00f3za. P\u0159i pokusech proveden\u00fdch na my\u0161\u00edch se uk\u00e1zalo, \u017ee u jedinc\u016f s p\u0159\u00edsunem resveratrolu se vytv\u00e1\u0159\u00ed daleko m\u00e9n\u011b tuku.<\/p>\n","protected":false},"excerpt":{"rendered":"